Royal Aussies of Virginia

  Welcome to our genetics page. We have done extensive research on the different testing companies that are on the market now and have found what we believe is the best option for your pup and your money and we are sharing our findings with you. Below we compared two of the more known/popular testing companies to one we personally use and believe to be the best at this time. We've attempted to break down a list of gene traits, which company offers testing of those traits and finally the list of results of our dogs.
 
Much of this information comes from other sites and took us a while to really understand it, if you have any questions please email us and we will do our best to give you as much information as possible.

Genetic testing comparison

We've taken time to compare these companies that offer genetic testing and break that down here. These companies do add/remove testing from time to time so if you find our information to be out of date please let us know so we can get it updated.
Note: As new tests for the Australian Shepherd breed become avalible we will be adding those to this list.
Company

MDR-1A mutation in the MDR-1 gene causes sensitivity to certain drugs. This mutation causes a defect in the P-glycoprotein that is normally responsible for transporting certain drugs out of the brain leading to a buildup of these toxins. A build up of these toxins can cause neurological symptoms such as, seizures, ataxia, or even death. Please note that even one copy of this mutation can cause sensitivity, just normally at a higher dose. (For a list of MRD sensitive drugs please see below)

DMDegenerative Melopothy is a progressive neurological disorder that affects the spinal cord of dogs. Dog with two copies of the defective gene can experience a breakdown of the cells responsible for sending and receiving signals from the brain.

CRM-1CRM-1 is a mutation that causes raised lesions to form on the retina. These lesions alter the appearance of the eye but does not affect sight. The lesions may disappear, or may result in minor retinal folding.

CDCD is a disease that causes degeneration of the retinal "cones" that respond primarily to bright daylight, resulting in day-blindness.

PRAPRA is when the cells in the dogs retina degenerate and die. Most dogs will not show signs of vision loss until 3-5 years of age and complete blindness in older dogs.

CEACEA is a bilateral eye disease common in aussies. This disorder causes abnormal development in layers of tissue in the eye under the retina called the choroid.

HUUHUU is a genetic mutation that metabolizes waste products as uric acid in their urine. The uric acid forms into hard stones in the bladder causing pain and inflammation as the stone moves through the urinary tract.

HCHC is the clouding of the lens of the eye caused by the breakdown of tissue in the eye. This can cause an inability to see clearly and can cause total blindness. Your dog only needs one mutation to have this appear later in life. Please note that not all cataracts are hereditary. Cataracts can also be caused by old age or injury.

Breed TestMany genetic tests are now advertising "Breed Tests" to see what breed your dog and its ancestors are. These are based off of what people claim and are known to be inaccurate on pure breed dogs. Although it's fun to see how these results turn out there is some degree of error so even a fully purebred dog will not always test as 100% purebred.

Other TestingOther/Unnecessary Tests - These companies provide generic DNA testing panels that aren't suited to any breed in particular. They test for several gene traits that might exist it one breed but not another. It's not so much that those tests don't provide value to all dogs but we work exclusively with Austrailian Shepherds and those traits don't apply to our breed, making these options not as cost effective as others.
* No wasted tests - Animal Genetics offers specific DNA panels per breed so they're only testing for traits that apply to the breed you've chosen, making your money go further and results more valuable.

Costs

Merle GeneIn most cases you will be able to tell you have a Merle pup due to the merle coloring but in some rare cases you can have what is called a Cryptic or Phantom Merle where your pup is not of merle coloring but still carries the gene. We offer this test for people who are looking to breed to ensure there is no opportunity to breed a double merle pup. We offer this as a test for both our pups and your potential breeder pup as well. This is mandatory if looking to breed.

Bobtail GeneThe bobtail gene is what causes aussies to be born with a naturally bobbed tail. We offer this as a test for breeders due to the fact that breeding two dogs with this gene is lethal in utero and can cause reduced litter sizes.

Hair Length MDR-1 Only
Embarkvet.com X Not Avail X Not Avail X Not Avail Not Avail X X - Read This X $199 Not Avail Not Avail Not Avail Not Avail
WisdomPanel.com X X X X X Not Avail Not Avail Not Avail X - Read This X $150 ($80 at Banfield) Not Avail Not Avail Not Avail Not Avail
Animal Genetics.us X X X X X X X X N/A No Wasted Tests* $180 $50 $40 $40 $55

Our dogs genetic test results.

Below are the test results for our individual dogs. n/n means the dog is cleared and does not carry that gene and cannot pass it onto it's offspring. For any other details please feel free to ask questions.
Company

MDR-1A mutation in the MDR-1 gene causes sensitivity to certain drugs. This mutation causes a defect in the P-glycoprotein that is normally responsible for transporting certain drugs out of the brain leading to a buildup of these toxins. A build up of these toxins can cause neurological symptoms such as, seizures, ataxia, or even death. Please note that even one copy of this mutation can cause sensitivity, just normally at a higher dose. (For a list of MRD sensitive drugs please see below)

DMDegenerative Melopothy is a progressive neurological disorder that affects the spinal cord of dogs. Dog with two copies of the defective gene can experience a breakdown of the cells responsible for sending and receiving signals from the brain.

CRM-1CRM-1 is a mutation that causes raised lesions to form on the retina. These lesions alter the appearance of the eye but does not affect sight. The lesions may disappear, or may result in minor retinal folding.

CDCD is a disease that causes degeneration of the retinal "cones" that respond primarily to bright daylight, resulting in day-blindness.

PRAPRA is when the cells in the dogs retina degenerate and die. Most dogs will not show signs of vision loss until 3-5 years of age and complete blindness in older dogs.

CEACEA is a bilateral eye disease common in aussies. This disorder causes abnormal development in layers of tissue in the eye under the retina called the choroid.

HUUHUU is a genetic mutation that metabolizes waste products as uric acid in their urine. The uric acid forms into hard stones in the bladder causing pain and inflammation as the stone moves through the urinary tract.

HCHC is the clouding of the lens of the eye caused by the breakdown of tissue in the eye. This can cause an inability to see clearly and can cause total blindness. Your dog only needs one mutation to have this appear later in life. Please note that not all cataracts are hereditary. Cataracts can also be caused by old age or injury.

Merle GeneIn most cases you will be able to tell you have a Merle pup due to the merle coloring but in some rare cases you can have what is called a Cryptic or Phantom Merle where your pup is not of merle coloring but still carries the gene. We offer this test for people who are looking to breed to ensure there is no opportunity to breed a double merle pup. We offer this as a test for both our pups and your potential breeder pup as well. This is mandatory if looking to breed.

Kovu n/n n/n n/n n/n n/n n/n n/n n/n n/n
Kiara n/M1 n/n n/n n/n n/P n/n n/n n/n -
Bailey n/M1 n/n n/n n/n n/n n/n n/n n/n -
Zira n/M1 n/n n/n n/n n/n n/n n/n n/n -
Our results enable us to guarantee that there is no chance of having a dominant gene abnormality in our puppies. Both our females are carriers of MDR-1 and Kiara is a carrier of PRA. Since Kovu has neither of those traits the offspring can only be carriers of those traits. The PRA gene trait will not cause problems as a recessive trait.
Please see the table below for more details about MDR-1.

When a dog is a carrier of the MDR-1 Gene it is at risk of having an adverse reaction to the drugs listed below if given higher doses.
If a dog has double MDR-1 (Dominant) gene it will have adverse reactions to the drugs listed below at any dosage.

It is important to know this ahead of time to prevent the use of the medications listed below as the results can be fatal.
Known MDR-1 Sensative Drugs
IvermectinCommonly found in heartworm medications
LoperamideImodium over the counter antidiarrheal agent
Doxorubicin
Vincristine
VinblatineAnti-Cancer agents
CyclosporinImmunosuppressive agent
DigoxinHeart drug
AcepromazineTranquilizer
Butorphanol"Bute" pain control
Possible MDR-1 Sensative Drugs
Ondansetron, Domperidone, Paclitaxel, Mitoxantrone, Etoposide, Rifampicin, Quinidine, Morphine